Your Impact:

Our Genetic Medicine team is advancing science to support non-viral based therapies that could deliver single treatment cures. In this role, you will work alongside our innovative scientists and leaders to advance science forward and make translational development a reality. Our objective at Poseida is to make gene therapies able to cure severe disease early in life: this is a daunting challenge, and we need your ingenuity to meet it.

Position Summary:

Poseida Therapeutics is searching for an outstanding and team-oriented experienced scientist to join our Gene Therapy Translational Development team in San Diego, CA. This position offers an excellent opportunity for a motivated individual to become a facilitator and a key driver in a nimble and innovative genetic medicine organization.

The qualified candidate must thrive working in a fast-paced innovative environment while remaining flexible, proactive, resourceful, and efficient. This candidate is a highly motivated, interactive, and creative team player with a passionate vision to drive research programs into a therapeutic reality.

This role will drive and facilitate gene therapy programs that work on several exciting targets with novel technologies capable of translation into highly durable, and potentially curative, therapies. This individual will interface with CROs and collaborate with our research partners to develop assays to support clinical development while collaborating cross functionally with in vivo gene therapy (R&D), genetic engineering (R&D), CMC, quality, and regulatory teams. This role will drive and manage translational aspects to the discovery teams, support IND-enabling preclinical studies, manage translational communications strategies and KOL engagement as needed.

Responsibilities may include but are not limited to:

• Manage translational development activities from early discovery programs to IND-enabling preclinical studies.
• Lead internal development efforts on translational in vivo studies and assays including safety-related (immunogenicity, genotoxicity, systemic and organ toxicity) and biomarker analysis.
• Lead drug discovery efforts for gene therapy programs, as needed.
• Support the design, execution, and interpretation of pharmacology and GLP toxicology experiments across the portfolio including interactions/management of external CROs.
• Provide interpretation and communicate translational learnings from emerging data internally & externally; provide data-based recommendations for internal decision-making.
• Support regulatory filings particularly for translational/clinical considerations.
• Facilitate storyboarding including internal / external scientific communications strategy.
• Contribute to due diligence efforts relating to KOL and possible external collaborations including clinical site interactions/support as needed.
• Support in vivo gene therapy and genetic engineering teams in early thinking on translatability of concepts to clinic.
• Evaluate new technologies and assays that will enhance understanding of the parameters associated with clinical biomarker response.
• Mentor junior lab scientists as needed.
• Ability to manage several projects simultaneously and smart research operations.

Requirements, Knowledge, Skills, and Abilities:

• Ph.D., master's, or bachelor's degree with 10+ years of relevant experience in drug discovery and development settings, with preference for experience with gene therapy products (an equivalent combination of education and experience may be considered).
• Demonstrated scientific acumen and mechanistic understanding of disease biology.
• Demonstrated ability to manage programs from discovery through lead optimization, IND-enabling execution all the way to setting up early clinical proof of concept is nice to have.
• Strong understanding of drug development and regulatory processes.
• Experience in managing and assimilating non-clinical data packages for therapeutic candidates for gene therapy. Any experience with cellular therapy drug development is a plus.
• Ability to work productively with, and influence, diverse project leads and work with cross-functional teams.
• Self-motivated and ambitious with a strong work ethic, with excellent organizational and time-management skills.
• Effective communication and strategic planning are essential for success.
• Excellent verbal and written communication skills, strong presentation skills, and demonstrated ability to manage by influence and problem-solving in a highly matrixed organization.
• Ability to build strong relationships with co-workers of various backgrounds and expertise.
• Prior experience managing CROs is a plus.
• Enjoys mentoring and inspiring co-scientists.
• Knowledge of nucleic acid, non-viral lipid nanoparticles, ex vivo cell therapy and in vivo gene therapy, and/or PK/PD and toxicology studies, expertise in immunology, liver, and muscle disorders is a plus.

Associate Director, Translational Science Pay Rate: $154,000 to $173,000 annually

The final pay offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience with the industry, education, geographic location, etc.

Who We Are and What We Do

Based in San Diego, Poseida Therapeutics is a clinical-stage biopharmaceutical company utilizing our unique and proprietary genetic engineering platform technologies to create next-generation cell and gene therapies with the capacity to cure. We are passionate about making an impact on patients' lives with the development of our CAR-T therapies in various cancers and gene therapies for rare diseases. Our goal is to deliver potential single treatment cures for patients in need. Our portfolio of product candidates is specifically designed to overcome the limitations of current generation cell and gene therapeutics.

At Poseida we put people first. Our team is passionate about improving patients' lives through innovation. See what our team has to say about our culture:

"My favorite part about Poseida is all the people that I get to work with. Everyone is so passionate about what we're doing here and there's so much camaraderie. It feels like one big enthusiastic family."

"My favorite part about working at Poseida is the amazing culture and working environment. Everybody is friendly, professional, collaborative, and has a remarkable can-do and positive attitude."

As we advance our compelling pipeline, there are endless opportunities for impact and growth. We encourage you to apply today!

Recruitment Fraud Alert

Alert: Beware of Employment Scams

Poseida Therapeutics, Inc. has received reports of employment-related scams. These scams have appeared in forms of false job advertisements and/or unsolicited contacts via communication/chat platforms, phone, email or text from individual(s) claiming to be or represent Poseida's Human Resources team. Be advised that Poseida Therapeutics does not extend unsolicited employment offers. Furthermore, Poseida Therapeutics does not request payment information or charge prospective employees with any fees during the recruitment process.

If you would like to pursue employment opportunities with Poseida Therapeutics, Inc., please visit our official careers website https://poseida.com/careers-culture/ or official Poseida Therapeutics LinkedIn page. Job postings that do not link directly to our careers website or official Poseida LinkedIn page are not legitimate and might be fraudulent. You may report fraudulent job advertisements or contacts via our Contact Us page at https://poseida.com/contact-us/ and select the subject "Careers." If you have been defrauded or suspect identity theft as a result of an employment scam, please contact your local law enforcement agency for guidance.